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ONCOLOGY LETTERS 7: 493498,Inhibitory effects of Dendrobium candidum Wall ex Lindl. on azoxymethane and dextran sulfate sodiuminduced colon carcinogenesis in C57BL/6 miceQIANG WANG, PENG SUN, GUIJIE LI, KAI ZHU, CUN WANG and XIN ZHAO Division of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, P.R. China Received Could 4, 2013; Accepted November eight, 2013 DOI: ten.3892/ol.2013.1728 Abstract. Dendrobium candidum Wall ex Lindl. was bought for the evaluation of azoxymethane (AOM) and dextran sulfate sodium (DSS)induced colon carcinogenesis in C57BL/6 mice. The physique weights with the AOM and DSSinduced colon cancer control groups had been lighter than these of your untreated mice. D. candidum increased the physique weights of the mice compared together with the handle group, and lowered the levels of your serum proinflammatory cytokines, IL6, IL12, TNF and IFN , compared using the colon cancer handle group. Reverse transcriptionpolymerase chain reaction and western blot analyses in the apoptoticrelated genes, bax, bcl2, caspase3 and caspase9, had been performed inside the colon tissues.Price of D-Glucal The highconcentration D.4-Hydroxynicotinonitrile Chemical name candidum group showed a significant increase in the mRNA and protein expression levels of bax, caspase3 and caspase9 and decreased expression levels of bcl2 compared with the control group.PMID:24631563 These outcomes indicate that D. candidum Wall ex Lindl. exhibits preventive effects against colon carcinogenesis in mice. Introduction Dendrobium may be the second biggest genus within the loved ones Orchidaceae, exhibiting a vast diversity of floral and vegetative characteristics and becoming of considerable importance as a result of its broad geographic distribution and highvalue hybrids purchased as a floricultural commodity (1). The stems on the Dendrobium species are known as Shihhu in Chinese, as sekkoku in Japanese and as Dendrobium stems in English (two). Dendrobium candidum Wall ex L.