Individuals have been treated with meropenem/vaborbactam, of which 3 (42.9 ) were for suspected VAP.Int. J. Mol. Sci. 2023, 24,five ofTable 2. Clinical traits of individuals with mutant KPC-Kp.Sex/Age Principle Diagnosis ARDS COVID-19 Comorbidities AH, NIDDM, Obesity, malignancy COVID-19 Time from ICU Admission three KPC Mutant Specimen KPC Sensitive Isolation Yes Prior Infections A. baumannii Intestinal Colonization no Earlier BroadSpectrum ATB yes Preceding Antifungal Therapy no CZA Treatment before Isolation no In-Hospital MortalityF/YesRSno VAP E. coli, MRSA, A. baumannii, KPC + BSI MRSE, KPC, E. faecium. Serratia marcescens + Pseudomonas in BAL, CMV, BSI MRSE. BSI A. baumannii, SSTI VRE BSI H. influenzae, MRSE, S. marcescens, P. aeruginosa. VAP H. influenzae VAP H. influenzae, CAPA VAP A. baumannii, KPC, MSSA VAP A. baumannii, KPC, K. oxytoca, P.Ethyl 2-bromothiophene-3-carboxylate site aeruginosa; C. difficile, BSI MRSE + CandidanoM/HAP in COVID-YesBlood, UCYesyesyesyesyesyesM/Difficult weaning Pulmonary embolism in trauma (vv-ECMO) Tricky weaning in H.1220039-63-3 site influenzae SCAP ARDS COVID-19 ARDS COVID-Smoker, COPDNoBALYesyesyesyesyesYesM/ObesityNoBALYesyesyesnoyesnoF/NoRSYesnoyesyesnoyesM/49 F/Obesity AH, autoimmune disease Earlier smoker, haematological diseaseYes Yes15RS RSYes Yesno noyes yesno Yesno nono yesM/ARDS COVID-YesRSNoyesnononoyesM/Difficult weaningAH, COPD, smokerNoRSYesyesyesyesnoyesInt. J. Mol. Sci. 2023, 24,6 ofTable 2. Cont.Sex/Age Principle Diagnosis ARDS COVID-19, pulomonary embolism in ECMO VV ARDS COVID-19 ARDS COVID-19 ARDS COVID-19 Comorbidities COVID-19 Time from ICU Admission KPC Mutant Specimen KPC Sensitive Isolation Previous Infections A. baumannii Intestinal Colonization Earlier BroadSpectrum ATB Earlier Antifungal Therapy CZA Remedy ahead of Isolation In-Hospital MortalityF/AH, NIDDM, obesityYesRSYesVAP MRSE + K.PMID:24120168 aerogenes VAP E. coli + S. marcescens, CAPA UTI E. faecalis + E. coli, BSI S. capitis, UTI E. coli VAP P. aeruginosa, CAPAyesyesnononoF/obesity AH, haematological illness AH AH, obesity, NIDDM, respiratory and autoimmune illness autoimmune disease autoimmune illness, respiratory disease, CKD Preceding smoker, NIDDM, CRF, Obesity, Malignancy, CKDYesRSYesnoyesyesnonoF/YesRS, bloodYesnoyesnononoF/YesRSNonoyesyesyesyesF/ARDS COVID-YesRSYesVAP MRSA + ProteusnoyesyesnonoM/ARDS COVID-YesRSYesVAP P. aeruginosa, BSI C. albicans, C. auris colonization. VAP P. aeruginosanoyesyesnoyesM/ARDS COVID-YesRSNonoyesnonoyesM/ARDS COVID-YesRSYesnoyesyesnoyesAbbreviations: ARDS: acute respiratory distress syndrome, AH: arterial hypertension, BAL: broncoalveolar lavage, VAP: ventilator related pneumonia, BSI: blood-stream infection, CAPA: COVID-19 Related Pulmonary Aspergillosis, CKD: chronic kidney disease, COPD: Chronic obstructive pulmonary illness, CRF: chronic renal failure, HAP: hospitalacquired pneumoniae, KPC: Klebsiella pneumoniae carbapenemase, MRSE: Methicillin-Resistant Staphylococcus epidermidis, MSSA: methicillin-sensitive Staphylococcus aureus, NIDDM: non-insulin-dependent diabetes mellitus, RS: rectal swab, SCAP: Extreme Community-Acquired Pneumonia, SSTI: Skin and soft tissue infections (SSTI).Int. J. Mol. Sci. 2023, 24,7 of3. Discussion Within this study we retrospectively reported on a cohort of seventeen critically ill patients enrolled over nine months through the COVID-19 pandemic, all of whom developed intrahospital colonization or infection because of mutant-KPC-33 Kp with resistance to C/A, mostly without having earlier C/A treatment. Even though.